;(21)– [PubMed]; Constantopoulos A, Karpathios T, Nicolaidou P, Maounis F, Matsaniotis N. Lazy-leukocyte syndrome. A case report . The lazy leukocyte syndrome was first described by Miller et al. in in two children with recurrent infection. They had normal humoral and cellular immunity . – LAZY LEUKOCYTE SYNDROME. LAZY LEUKOCYTE SYNDROME. Clinical Synopsis Toggle Dropdown. Inheritance. -? Autosomal dominant new.

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A new disorder of neutrophil function.

Lazy leukocyte syndrome.

Unfortunately, it is not free to produce. Autosomal dominant new mutations. Both random mobility and chemotactic function were defective. Expert curators review the literature and organize it to facilitate your work.

Bone marrow studies showed normal numbers of mature, morphologically normal neutrophils. A severe neutropenia was found. The syndrome is distinguished from neutrophil chemotactic deficiencies by the coexistence of defective random motility and peripheral blood neutropenia with normal bone marrow synfrome reserve.


Lazy leukocyte syndrome.

Looking For More References? A characteristic abnormality of actin distribution in neutrophils was demonstrated.

Pathology of chemotaxis and random mobility. OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine.

Mobilization of leukocytes after exercise was defective. Transient ‘lazy-leukocyte’ syndrome during infancy. Please consider making a donation now and again in the future.


We need long-term secure funding to provide you the information that you need at your fingertips. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions. Single cases were reported by Costanopoulos et al. Clinical Synopsis Toggle Dropdown.

lazy leukocyte syndrome

A poor neutrophil response was obtained upon stimulation with both epinephrine and endotoxin, as well as upon induced inflammation by the Rebuck skin window technique. Relative to the genetics and the possibility that these cases represent leukodyte dominant mutations, parental age data would be of interest.


Leukocyte phagocytosis and bactericidal activity were normal.

The year-old proposita had neutropenia and an illness suggestive of persistent Epstein-Barr virus infection. We are determined to keep this website freely accessible.

Miller knew of 4 other cases. A bonus to all MIMmatch users is the option to sign up for updates on new gene-phenotype relationships. None is familial and no parental consanguinity is known. Skin window mobilization test and chemotaxis were normal. The same abnormality probably leads to impaired deformability of neutrophils so xyndrome release of newly formed neutrophils from the bone marrow is reduced.