Síntesis de nitroderivados de hidroxitirosol como potenciales inhibidores de COMT. Article in Basic & Clinical Pharmacology & Toxicology · January . The principle aim of COMT inhibitor therapy is to increase the duration of El principal objetivo del tratamiento con inhibidores de la COMT es. AMPT: α-metil-p-tirosina; COMT: catecol-O- . gena en la circulación, primero son metiladas por la COMT y con- Existen también inhibidores de la COMT.

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Catechol-O-methyltransferase – Wikipedia

Principles of pharmacology 3rd ed. A functional single-nucleotide polymorphism a common normal variant of the gene for catechol-O-methyltransferase inhbiidores in a valine to methionine mutation at position Val Commt rs Journal of Oral Rehabilitation. Views Read Edit View history. The best-studied is ValMet. However, there seems to be a trend for tolcapone to induce more often diarrhoea and increase in liver transaminases compared with entacapone.

Journal of Alzheimer’s Disease. Entacapone acts mainly peripherally whereas tolcapone acts both peripherally and centrally. The enzyme introduces a methyl group to the catecholamine, which is donated by S-adenosyl methionine SAM.

ES2282924T3 – Inhibidores de la comt. – Google Patents

Betaine-homocysteine methyltransferase Homocysteine methyltransferase Methionine synthase. Molecular and Cellular Biology portal. Two of inhibidotes nitrocatechols, entacapone As the regulation of catecholamines is impaired in a number of medical conditions, several pharmaceutical drugs target COMT to alter its activity and therefore the availability of catecholamines.


The Journal of Biological Chemistry.

The Central Nervous System. Histamine N-methyltransferase Diamine oxidase. This article relies too much on references to primary sources. Serine hydroxymethyltransferase 3-methyloxobutanoate hydroxymethyltransferase.

Genes on human chromosome 22 EC lnhibidores. Thus, COMT inhibitors are clinically significant and beneficial adjunct to levodopa therapy in Parkinson’s disease patients with end-of-dose fluctuations. The dyskinesias are managed by decreasing the daily levodopa dose in Parkinson’s disease patients with end-of-dose fluctuations.

When given with an inhibitor of dopa decarboxylase carbidopa or benserazidelevodopa is optimally saved.

COMT inhibition in the treatment of Parkinson’s disease.

All articles with dead external links Articles with dead external links from November Articles with permanently dead external links Articles lacking reliable references from December All articles lacking reliable references Commons category link is on Wikidata. Any compound having a catechol structure, like catecholestrogens and catechol-containing flavonoids, are substrates of COMT.

They induce a dose-dependent inhibition of COMT activity in erythrocytes and a significant decrease in the plasma levels of 3-O-methyldopa, indicating their effectiveness as COMT inhibitors.

More reference expression data. Tyrosine hydroxylase Aromatic L-amino acid decarboxylase Dopamine beta-hydroxylase Phenylethanolamine N-methyltransferase. It is increasingly recognised that allelic variation at the COMT gene are also relevant for emotional processing, as they seem to influence the interaction between prefrontal and limbic regions.

In the brain, COMT-dependent dopamine degradation is of particular importance in brain regions with low expression of the presynaptic dopamine transporter DATsuch as the prefrontal cortex. Tryptophan hydroxylase Aromatic L-amino acid decarboxylase Aralkylamine N-acetyltransferase Acetylserotonin O-methyltransferase.


Both entacapone and tolcapone are well-tolerated.

EST3 – Inhibidores de la comt. – Google Patents

Their effects and significance also in the treatment of de novo patients need to be clarified. Cholinesterase AcetylcholinesteraseButyrylcholinesterase.

Research conducted at the Section of Neurobiology of PsychosisInstitute of Psychiatry, King’s College London has demonstrated an effect of COMT both in patients with bipolar disorder and inhibidoges their relatives, [36] [ unreliable medical source ] but these findings have not been replicated so far. In other projects Wikimedia Commons. Phosphoribosylglycinamide formyltransferase Inosine monophosphate synthase.

However, tolcapone is clinically restricted owning to its increased hepatotoxicity and other related digestive disorders.

COMT is the name given to the gene that codes for this enzyme. The American Journal of Psychiatry. Lay summary — MedWireNews. Enzymes involved in neurotransmission.

Retrieved from ” https: Both pharmacokinetically and clinically the mg dose of entacapone is the most effective dose compared with placebo. Hydroxymethyltransferase Serine hydroxymethyltransferase 3-methyloxobutanoate hydroxymethyltransferase. For tolcapone and mg have most often proved to be the optimal doses. The O in the name stands for inhibidorfsnot for ortho. Student consult 7th ed.